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KMID : 0352119890050010087
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Journal of Kyung Hee University
1989 Volume.5 No. 1 p.87 ~ p.96
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THE EFFECT OF PAEDOKSAN ON THE GOUT INDUCED BY MICROCTY-STALLIME SODIUM URATE IN RATS
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Abstract
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In order to investigate experimentally the effect of I= aedoksan on the gout induced by microctystalline Sodium urate in rats, solid extract of Paedoksan were a dminstrated.
And then metatarsophalangeal joint swelling, analge-
s is effect, erythrocyte segmentation rate and white
t lood cell count were measured and serum uric acid, serum creatimine, urine uric acid and urine creatinine there studied.
The group were divided into control group, 243, 2 mg/ 00 g of solid extract of Insampaedoksan administered group (Sample A group) and 486.4 mg/200 g of solid extract of Insampaedoksan ad%inistered group (Sample 3 group). The results were obtained as follows
1) Metatarsophalangeal joint swelling was decreased with statistical significance after administrating Sam-)le A and Sample B 4hrs. larter. And metatarsophalan-4eal joint swelling was also remarkably inhibited after administrating Sample A and Sample B after 4hrs. later.
2) The analgesic effects were recognized in all the sample groups after administrating; 3, 4, and 5hrs. later.
Especially after 4hrs., analgesic effects were highly recongnozed in all the sample groups.
3) For the erythrocyte segmentation rate, Sample B group showed some decrease compared with control group, and for the white blood cell count, all the sample groups showed remarkable decrease, compared with control group.
4) Serum uric acid was decrease in Sample B group and serum creatinine was decreased highly significantly in all the sample groups compared with control group.
urine uric acid and urine creatinine was decreased with significance in all the sample grups compared with control group.
According to the above results, solid extract of Insampaedoksan was effective on the gout induced by microcrystalline sodium urate and it is suggested that Insampaedoksan could be recommended for the treatment of gout in clinics.
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